Blar i forfatter "Brech, Andreas"

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    • The FMRpolyGlycine protein mediates aggregate formation and toxicity independent of the CGG mRNA hairpin in a cellular model for FXTAS 

      Hoem, Gry; Larsen, Kenneth Bowitz; Øvervatn, Aud Karin; Brech, Andreas; Lamark, Trond; Sjøttem, Eva; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-28)
      Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder caused by a CGG-repeat expansion in the 5′ UTR of the FMR1 gene on the X-chromosome. Both elevated levels of the expanded FMR1 mRNA and aberrant expression of a polyglycine protein (FMRpolyG) from the CGG-repeat region are hypothesized to trigger the pathogenesis of FXTAS. While increased expression of FMRpolyG leads ...

    • Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer 

      Puvirajesinghe, Tania M.; Bertucci, François; Jain, Ashish; Scerbo, Pierluigi; Belotti, Edwige; Audebert, Stéphane; Sebbagh, Michael; Lopez, Marc; Brech, Andreas; Finetti, Pascal; Charafe-Jauffret, Emmanuelle; Chaffanet, Max; Restouin, Audrey; Marchetto, Sylvie; Collette, Yves; Gonçalvès, Anthony; Macara, Ian; Birnbaum, Daniel; Kodjabachian, Laurent; Johansen, Terje; Borg, Jean-Paul (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-12)
      The non-canonical Wnt/planar cell polarity (Wnt/PCP) pathway plays a crucial role in embryonic development. Recent work has linked defects of this pathway to breast cancer aggressiveness and proposed Wnt/PCP signalling as a therapeutic target. Here we show that the archetypal Wnt/PCP protein VANGL2 is overexpressed in basal breast cancers, associated with poor prognosis and implicated in tumour ...

    • Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy 

      Mejlvang, Jakob; Olsvik, Hallvard Lauritz; Svenning, Steingrim; Bruun, Jack-Ansgar; Abudu, Yakubu Princely; Larsen, Kenneth Bowitz; Brech, Andreas; Hansen, Tom Egil; Brenne, Hanne Britt; Hansen, Terkel; Stenmark, Harald Alfred; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-17)
      It is not clear to what extent starvation-induced autophagy affects the proteome on a global scale and whether it is selective. In this study, we report based on quantitative proteomics that cells during the first 4 h of acute starvation elicit lysosomal degradation of up to 2–3% of the proteome. The most significant changes are caused by an immediate autophagic response elicited by shortage of amino ...

    • Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake 

      Jakobi, Arjen J.; Huber, Stefan T.; Mortensen, Simon A.; Schultz, Sebastian; Palara, Anthimi; Kuhm, Tanja; Shrestha, Birendra Kumar; Lamark, Trond; Hagen, Wim J.H.; Wilmanns, Matthias; Johansen, Terje; Brech, Andreas; Sachse, Carsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-23)
      p62/SQSTM1 is an autophagy receptor and signaling adaptor with an N-terminal PB1 domain that forms the scaffold of phase-separated p62 bodies in the cell. The molecular determinants that govern PB1 domain filament formation in vitro remain to be determined and the role of p62 filaments inside the cell is currently unclear. We here determine four high-resolution cryo-EM structures of different human ...

    • TRIM27 is an autophagy substrate facilitating mitochondria clustering and mitophagy via phosphorylated TBK1 

      Garcia, Juncal Garcia; Berge, Anne Kristin McLaren; Overå, Katrine Stange; Larsen, Kenneth Bowitz; Bhujabal, Zambarlal Babanrao; Brech, Andreas; Abudu, Yakubu Princely; Lamark, Trond; Johansen, Terje; Sjøttem, Eva (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-16)
      Tripartite motif-containing protein 27 (TRIM27/also called RFP) is a multifunctional ubiquitin E3 ligase involved in numerous cellular functions, such as proliferation, apoptosis, regulation of the NF-kB pathway, endosomal recycling and the innate immune response. TRIM27 interacts directly with TANK-binding kinase 1 (TBK1) and regulates its stability. TBK1 in complex with autophagy receptors is ...